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CXCL12/CXCR4 signaling contributes to neuropathic pain via central sensitization mechanisms in a rat spinal nerve ligation model.

CNS Neurosci Ther. 2019;

LiuZhi-Yuan，SongZhi-Wen，GuoShi-Wu，HeJun-Sheng，WangShen-Yu，ZhuJian-Guo，YangHui-Lin，LiuJi

Products/Services Used	Details	Operation
Peptide Synthesis	… 2.2 \| Drugs and antibodies Rat recombinant CXCL12 peptide (Z02860) was purchased from Genscript (Piscataway, NJ, USA). CXCR4 antagonists AMD3100 (A5602) and Astrocyte metabolic inhibitor fluorocitrate (F9634) were purchased from Sigma (St. Louis, MO, USA) …	Get A Quote

摘要

Previous studies have demonstrated that the CXCL12/CXCR4 signaling axis is involved in the regulation of neuropathic pain (NP). Here， we performed experiments to test whether the CXCL12/CXCR4 signaling pathway contributes to the pathogenesis of neuropathic pain after spinal nerve ligation (SNL) via central sensitization mechanisms.